Distance wise it is not really that far away as Ireland is a small country. You can go all the way from Dublin to Donegal via bus in about 5 hours or so travel time.
It seems that most of my relatives were from southern Ireland but the main branch of MY family is in Donegal. 
I've been there to check it out and see the historical sites that belong to my family who still live there in large numbers. They migrated south to fight the English in the Battle of Kinsale which was in ~1600. That is how they ended up in Tipperary.
Ironically, I found out that my husband's family was also present at the Battle of Kinsale. There were two brothers of his surname that fought in that battle and both of them are names in my husband's family, including himself! Now how is that for beyond bizarre?
They could have well been from Mayo and relocated to Wexford as some point. It is so difficult to know.
If you ever find any links to San Francisco, let me know as I have quite a stockpile of info. on the Irish living there from the mid-1800s to present day.
Best of luck to you too and I hope that some day you get a letter from someone that is looking for YOU. I cannot tell you how that makes one feel. Worthy at last!! 
YES.
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