First off consider community college for the first couple of years or three. It doesn't sound like your grandson is going to need any remedial work at all, but for those that do it's much cheaper to do that at a community college if working on their own doesn't fix the problem. So, your grandson won't need that, but credits at community college are much cheaper. Sometimes the classes are actually better than at universities. If you get those two years out of the way it will be a lot lighter on the wallet. I just got my two year degree myself and I am transferring to the U of M in the fall.
An option you can use in conjunction with this or separately is find a job where they will match your college funds. That comes with a couple of catches or three or four though. First catch, you usually have to work there for a year before you can qualify. Second, the classes have to be something that can contribute to your job, so if you go to Target for example classes in accounting will qualify, but Forestry classes not so much. Third, you have to pay out of pocket and you are reimbursed after completing the classes. Forth you have to remain employed at the company while taking classes.
Another option which is difficult to pull off is to become employed at a university, many offer free classes to their employees.
Hope this helps.