Half of Heart Attacks in Younger Women Aren't From Clogged Arteries

[littlemissmartypants]

Half of Heart Attacks in Younger Women Aren't From Clogged Arteries
Health
25 September 2025
By David Nield

Traditionally, most heart attacks have been blamed on clogged arteries causing atherothrombosis – where blood clots block flow to the heart. But new research suggests we may be underestimating the role of other causes, particularly in younger adults.

Scientists from the Mayo Clinic in the US analyzed 1,474 heart attack cases in people aged 65 or younger, recorded between 2003 and 2018 in Olmsted County, Minnesota. By carefully reviewing medical records and imaging, they identified a primary cause behind each case.

Atherothrombosis accounted for 75 percent of heart attacks in men, which wasn't surprising. In women, it was the cause of 47 percent – less than half. That has major implications for the prevention and treatment of heart attacks.

"This research shines a spotlight on heart attack causes that have historically been under-recognized, particularly in women," says cardiologist Claire Raphael.

There were significant differences in heart attack causes between men and women. (Raphael et al., J. Am. Coll. Cardiol., 2025)
Snip...more
https://www.sciencealert.com/half-of-heart-attacks-in-younger-women-arent-from-clogged-arteries


❤️ pants
RESIST!! ✊️

[NJCher]

1. SSDM is?

Article doesn’t say.

[AllyCat]

2. I really had to look and could only find paywalled

Science articles. “Supply demand mismatch” but no ability to get further information.

I feel like science alert is trying to get information from journals into some readable form as it is all over social media. It’s just got an AI feel to it for me.

[erronis]

10. I imagine you are right. There are a lot of online regurgitators, even in the realm of science and medicine.

I've learned to spot several signs in the way sentences/paragraphs/articles are put together.

That, without proper attribution to the original sources is a pet peeve. (I can't have cats or dogs, so I have peeves.)

[Festivito]

14. Tom Wade MD seems to be the SSMD guy. Or is he AI SMD invention?

This entry was posted in Journal of the American College of Cardiology, Medscape Medical News, MI Due To Atherosclerosis, MI Due To Embolism, MI Due To Spontaneous Coronary Artery Dissection (SCAD), MI Due To Supply-Demand Mismatch (SSDM), MI Due To Vasospasm, MI With Nonobstructed Coronary Arteries Of Unknown Cause (MINOCA-U).

https://www.tomwademd.net/linking-to-and-excerpting-from-medscape-medical-news-more-than-half-of-heart-attacks-in-younger-women-have-nontraditional-causes/

It all links back to Tom Wade

[markodochartaigh]

3. Like any muscle the heart requires a certain amount of oxygen.

“Supply-demand mismatch is fundamentally a marker of severe systemic illness rather than a primary cardiac event, and its prognosis is largely driven by the underlying noncardiac disease burden.”


https://www.medscape.com/viewarticle/more-than-half-heart-attacks-younger-women-have-2025a1000ob0


"For example, both hypoxia and anemia can decrease oxygen carrying capacity, leading to an imbalance secondary to supply mismatch. This may result in ischemia, which, if severe enough, may lead to myocardial cell death with symptoms and/or ECG changes."


https://www.medscape.com/viewarticle/more-than-half-heart-attacks-younger-women-have-2025a1000ob0

?si=9Q5txY_7eqO8tHgT

?si=9Q5txY_7eqO8tHgT

[littlemissmartypants]

5. I'm sorry Cher. I stepped away from DU for breakfast and Nollie.

Here's the link to the study summary. Which gets more to the just of the matter. It's pay walled. But it hits the highest points that made the difference in the results.

https://www.jacc.org/doi/10.1016/j.jacc.2025.07.012

I hope you have a wonderful day.

❤️

[NJCher]

13. thanks, LMSP

It is indeed good to hear research is being done on women, and younger women, at that.

[Wicked Blue]

9. Secret Signal Delayed Mapping

[NJCher]

12. thank you

[Chicagogrl1]

4. Not Surprising

So are doctors going to treat women differently now, instead of shoving statins down our throats?

[littlemissmartypants]

6. Good question. Heart disease is so prevalent in my family an MI is my worst-case scenario. ❤️

[LittleGirl]

7. I've got thyroid disease and

it causes high cholesterol (at least in my family). They tried to get me on statins 30 years ago and the leg cramps woke me up at night. I quit taking them within a week. I refuse to take them. I take fish oil instead. And got my thyroid treated finally which lowered everything.

[Chicagogrl1]

11. Exactly!!

[Deep State Witch]

8. Nah

Just tell you to "lose weight" and exercise.